Chemical probes of DNA structure in chromatin
نویسندگان
چکیده
منابع مشابه
Organization of DNA in chromatin ( chromatin structure / intercalation / DNA - kinking )
Conformational changes in DNA that accompany drug intercalation have led us to ask if DNA first bends or "kinks" to accept an intercalative drug or dye. Kinking is made possible by altering the normal C2' endo deoxyribose sugar ring puckering in B DNA to a mixed sugarpuckering pattern of the type C3' endo (3'-5') C2' endo and partially unstacking base-pairs. A kinking scheme such as this would ...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 1995
ISSN: 1074-5521
DOI: 10.1016/1074-5521(95)90066-7